The Prevention of Second Primary Cancers: A Resource for Clinicians and Health Managers
Karger Medical and Scientific Publishers, 1 sty 2008 - 147
A second primary cancer (SPC) is a new primary cancer developing in a person with a history of cancer at a new site or tissue and subsequent to the initial cancer. Advances in cancer treatment have led to marked improvements in cancer cure rates over the past 30 years, and the control of risk factors has further increased longevity. Still, cancer survivors are at increased risk not only for recurrence of the primary cancer but also for the development of second primary malignancies, the latter being especially true for survivors of childhood cancer. SPCs are now more common, and research into them has intensified.This monograph provides a synthesis of the current research on SPC, culminating in pertinent summary charts, covering the whole spectrum of first and second primary cancers and the association between them. Readers will gain a general understanding of the epidemiology and of the excess risk of SPCs following an implicated first malignancy. The known or suspected etiologic factors for SPCs are identified, and the field is further narrowed to those factors that are modifiable in practice. Effective preventive measures that might reduce the burden of SPC, both for individuals and across at-risk populations, are presented.Providing practical guidance in terms of possibilities and priorities, this monograph will be a valuable tool for oncologists, general practitioners and health administrators.
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1Overview of the Topic
2Meaning of SPC
3Importance of SPC
4Framework and Methodology
7Breast Cancer Female
15Summary of Significant SPC Associations
16Population Health Priorities
9Cancers of the Head and Neck
acute lymphocytic leukemia Adapted aerodigestive tract associated bladder cancer breast cancer cancer following cancer patients cancer registries cancer SPC Overall cervical cancer chemotherapy childhood cancer survivors Clin Oncol colorectal cancer epidemiologic etiologic excess risk exposure Figures in parentheses genetic head and neck Hemminki Hodgkin’s disease incidence increased risk Int J Cancer Kidney laryngeal cancer late effects long-term lung cancer melanoma metachronous Multiple Primary Cancers myeloid leukemia Natl Cancer Inst neck cancer non-Hodgkin’s lymphoma nonmelanoma skin cancer oral oropharyngeal Pancreas parentheses are 95 pediatric cancer population-based Prevention of Second primary malignancies prostate cancer radiotherapy retinoblastoma risk factors risk of second risk of SPC salivary gland second cancer Second Primary Cancers Second primary tumors small intestine smoking solid tumors SPC following SPC Overall SIR SPC risk squamous cell carcinoma Stomach surveillance Table testicular cancer thyroid cancer thyroid gland treatment upper aerodigestive tract Wilms tumor