Hepatobiliary DiseasesJesus Prieto, Joan Rodes, David A. Shafritz Springer Science & Business Media, 6 gru 2012 - 1128 The last few years have witnessed major developments in molecular biology which have had a significant impact on biomedical knowledge. As a result new concepts in cell biology have emerged, new etiologic agents have been discovered, and new drugs have become available. Furthermore, the world of mediators, cytokines, and humoral factors has enlarged considerably in a relatively short period and this has modified our views of diverse physio pathologic processes as well as opened up new therapeutic prospects. In addition, recent technologic advances have revolutionized our diagnostic methodology and have greatly enhanced the power of our therapeutic resources. All these factors have contributed to a substantial remodeling of both liver science and clinical hepatology, and these changes have generated the motivation for the production of the present book, which attempts to give an account of well-known clinical facts in the light of current thinking. It is the fruit of the coordinated work of experts from different countries in three continents. In a sense, it is a manifestation of the fact that inter national cooperation is becoming increasingly important not only in the expansion of science but also in its exposition. We hope that Hepatobiliary Diseases will be useful to both students and clinicians and that internists, gastroenterologists, and general practitioners will find in its contents a satifactory coverage of their field of interest. |
Spis treści
1 | |
27 | |
33 | |
Biochemical Investigations in the Management of Liver Disease | 39 |
yGlutamyltransferase | 51 |
Other Tests Sometimes Used to Investigate Liver Function | 57 |
The Use of Liver Function Tests | 64 |
Molecular Biology of the Liver | 73 |
Subacute Hepatitis Chronic Hepatitis and Cirrhosis | 715 |
Phospholipidosis and Alcoholiclike Liver Lesions | 717 |
Sclerosing Cholangitis | 718 |
Hepatic Tumors | 721 |
Diagnosis | 722 |
Treatment and Prevention | 725 |
Alcoholic Liver Disease M SALASPURO 729 | 728 |
Patterns and Pathology of Alcoholic Liver Disease | 732 |
Regulation of LiverSpecific Genes | 82 |
Immunology and the Liver | 95 |
Diagnostic Imaging of the Hepatobiliary System | 115 |
Hepatobiliary Computed Tomography | 124 |
Hepatic Magnetic Resonance Imaging | 130 |
The Role of Direct Morphologic Methods | 140 |
B Laparoscopy | 167 |
Bilirubin Metabolism and Hyperbilirubinemia | 181 |
Secretion and Intestinal Fate | 187 |
DubinJohnson Sydrome and Rotors Syndrome | 196 |
Anatomic and Physiologic Bases of Bile Formation | 212 |
Cholestasis | 222 |
Chronic Hepatitis and Cirrhosis | 281 |
Pathogenesis | 291 |
Clinical Features | 292 |
Biochemical Findings | 293 |
Diagnosis | 295 |
Natural History and Prognosis | 297 |
Management | 304 |
References | 313 |
B Cirrhosis J QUIROGA O BELOQUI and A CASTILLA | 323 |
Classification | 325 |
Pathogenesis | 328 |
Pathophysiology and Clinical Manifestations | 334 |
Metabolic Disturbances | 344 |
Systemic Derangements | 351 |
Infections and Noninfectious Fever | 381 |
Diagnosis | 385 |
Prognosis | 391 |
Treatment | 399 |
References | 405 |
PortalSystemic Encephalopathy J BIRCHER and W SOMMER 417 | 416 |
Clinical Presentation | 419 |
Clinical Investigation | 421 |
Management | 422 |
References | 426 |
Portal Hypertension J BOSCH J C GARCIAPAGÁN F FEU and M P PIZCUETA | 429 |
Pathophysiology | 430 |
Evaluation of the Portal Hypertensive Patient | 433 |
Natural History of Esophageal Varices | 440 |
Management of Variceal Hemorrhage | 442 |
Prevention of Variceal Hemorrhage | 450 |
Ectopic Varices | 456 |
Portal Hypertensive Gastropathy | 457 |
Extrahepatic Portal Hypertension | 458 |
Diagnostic and Therapeutic Approach to the Portal Hypertensive Patient | 459 |
References | 460 |
Ascites and Renal and Electrolyte Abnormalities in Cirrhosis V ARROYO and P GINÈS 465 | 464 |
Factors Involved in Ascites Formation in Cirrhosis | 468 |
Mechanism of Renal Function Abnormalities | 473 |
Pathogenesis of Ascites and Renal Dysfunction in Cirrhosis | 480 |
Reabsorption of Ascites | 482 |
Treatment of Ascites | 483 |
References | 490 |
Viral Hepatitis A and E A Type A Viral Hepatitis S M LEMON | 495 |
Natural History | 496 |
Clinical Findings | 500 |
Pathology | 502 |
Diagnosis | 503 |
Treatment | 504 |
Prevention | 506 |
References | 508 |
B Type E Viral Hepatitis D W BRADLEY and K KRAWCZYNSKI | 511 |
The Agent of Enterically Transmitted nonA nonB Hepatitis | 513 |
Serologic Assays and Immune Response | 522 |
Unanswered Questions | 523 |
References | 525 |
Viral Hepatitis B and D | 527 |
Hepatitis D Virus and Viral Hepatitis D | 554 |
Laboratory Tests | 561 |
Treatment | 563 |
Prophylaxis | 565 |
References | 567 |
Viral Hepatitis C | 573 |
The Virus | 575 |
Serologic Markers of Hepatitis C Virus | 576 |
Epidemiologic Aspects | 582 |
Hepatitis C Virus Infection in Chronic Liver Disease and Hepatocellular Carcinoma | 588 |
Pathogenesis of Hepatitis C | 594 |
Clinical and Histopathologic Aspects | 595 |
Treatment of Hepatitis C Virus Infection | 599 |
References | 602 |
Liver Involvement in Systemic Infection J GUARDIA V VARGAS and R ESTEBAN 611 | 610 |
Systemic Bacterial Infections | 618 |
Fungal Infections | 623 |
Granulomas of the Liver | 627 |
References | 628 |
Protozoal and Helminthic Diseases of the Liver and Biliary Tract L C DA SILVA P P CHIEFFI and F J CARRILHO | 631 |
Malaria | 634 |
Visceral leishmaniasis Kalaazar | 636 |
Ascariasis | 637 |
Fascioliasis | 642 |
Clonorchiasis and Opisthorchiasis | 643 |
Schistosomiasis | 645 |
Hydatidosis Echinococcosis | 651 |
Visceral Larva Migrans Systemic Toxocariasis | 654 |
Capillariasis | 655 |
Strongyloidiasis | 656 |
Pentastomiasis Porocephaliasis | 657 |
References | 659 |
The Liver in Pregnancy and in Systemic Diseases M BRUGUERA | 665 |
Liver Diseases Occurring During Pregnancy | 670 |
Pregnancy in Patients with Liver Disease | 672 |
The Liver in Systemic Diseases | 673 |
Connective Tissue Diseases | 681 |
Sarcoidosis | 685 |
Amyloidosis | 687 |
Inflammatory Bowel Disease | 690 |
Thyroid Disease | 693 |
References | 694 |
DrugInduced Liver Diseases D PESSAYRE | 697 |
Mechanisms Involved in Acute Hepatitis | 698 |
Clinicopathologic Aspects of Acute Hepatitis | 705 |
Bland Hepatocellular Cholestasis | 713 |
Steatosis | 714 |
Ethanol Metabolism | 734 |
Pathogenesis of Alcoholic Liver Disease | 741 |
Clinical Manifestations of Alcoholic Liver Disease | 748 |
Diagnosis and Differential Diagnosis of Alcoholic Liver Diseases | 751 |
Treatment and Prognosis of Alcoholic Liver Disease | 752 |
References | 755 |
Autoimmune Chronic Active Hepatitis K H MEYER ZUM BÜSCHENFELDE and M P MANNS | 757 |
Immunogenetics | 761 |
Etiology and Pathogenesis | 762 |
Clinical Features and Pathology | 763 |
Differential Diagnosis | 765 |
Therapy | 766 |
References | 767 |
Primary Biliary Cirrhosis and Sclerosing Cholangitis A PARÉS and J RODÉS | 771 |
Pathology | 772 |
Etiology and Pathogenesis | 773 |
Clinical Features | 775 |
Laboratory Tests | 779 |
Associated Diseases | 780 |
Diagnosis | 781 |
Differential Diagnosis | 782 |
Natural History and Prognosis | 783 |
Treatment | 784 |
B Primary Sclerosing Cholangitis 1 Etiology and Pathogenesis | 789 |
Pathology | 791 |
Clinical Features | 792 |
Cholangiographic Features | 793 |
Associated Diseases | 794 |
Treatment | 795 |
References | 796 |
Pathophysiology and Therapy S D ZUCKER and J L GOLLAN 801 | 800 |
Wilsons Disease | 804 |
Summary | 829 |
References | 830 |
Haemochromatosis L W POWELL K M SUMMERS and J W HALLIDAY | 835 |
Definitions and Classification | 840 |
Primary Genetic Haemochromatosis | 841 |
Secondary Acquired Haemochromatosis | 853 |
References | 855 |
a₁Antitrypsin Deficiency J M ZOZAYA and J PRIETO | 859 |
aAntitrypsin Deficiency and Liver Disease | 862 |
References | 866 |
The Porphyrias J PRIETO and J CAMPS | 869 |
The Heme Biosynthetic Pathway | 870 |
Classification of the Porphyrias | 872 |
Hepatic Porphyrias with Acute Neurovisceral Attacks | 873 |
Hepatic Porphyrias without Acute Neurovisceral Attacks | 878 |
Erythrohepatic Porphyria or Protoporphyria | 883 |
Secondary Porphyrinuria | 887 |
Pediatric Metabolic Liver Diseases A P MOWAT 893 | 892 |
Congenital or Neonatal Ascites | 894 |
Hepatic Glycogen Storage Diseases | 896 |
Galactose1phosphate Uridyl Transferase Deficiency | 898 |
Epimerase Deficiency Galactosaemia | 900 |
Tyrosinaemia | 904 |
Urea Cycle Disorders | 906 |
Rare Disorders with Hyperammonaemia and Disturbed Amino Acid Metabolism | 910 |
Defects in Pyruvate Metabolism Causing Lactic Acidosis | 911 |
Disorders with Hyperammonaemia and Massive Fat Accumulation in Hepatocytes | 912 |
Abetalipoproteinaemia | 915 |
Bile Salt Metabolism | 916 |
Defects in Bile Acid Synthesis | 917 |
Disorders of Lysosomal Enzymes | 920 |
Lipid Storage Disorders | 921 |
Mucopolysaccharidosis | 924 |
Progressive Neuronal Degeneration of Childhood with Liver Disease | 925 |
Familial Erythrophagocytic Lymphohistiocytosis | 926 |
References | 928 |
Disordered Embryogenesis of the Hepatobiliary Tract P VAN EYKEN and V DESMET | 931 |
Anatomic Anomalies of the Bile Ducts | 933 |
Atresia of Extrahepatic Bile Ducts | 936 |
Paucity of Intrahepatic Interlobular Bile Ducts | 946 |
Cystic and Dysplastic Lesions | 952 |
References | 967 |
Fatty Liver Disease and Nutritional Liver Damage J PRIETO J M ZOZAYA and F CONCHILLO | 971 |
Reyes Syndrome | 976 |
Fatty Liver Hepatitis Nonalcoholic Steatohepatitis | 978 |
Nutritional Liver Injury | 980 |
References | 981 |
Circulatory Disorders and Vascular Disease Affecting the Liver P A MCCORMICK and A K BURROUGHS | 983 |
Cardiomyopathy Associated with Cirrhosis | 984 |
The Effect of Ascites on Cardiac Function | 985 |
Atherosclerosis and Arterial Hypertension | 986 |
Heart Failure | 987 |
Hepatic Abnormalities in Other Cardiac Diseases | 988 |
Cardiac Surgery | 989 |
BuddChiari Syndrome | 990 |
Hepatic Venoocclusive Disease | 993 |
Systemic Vasculitis | 994 |
Nodular Regenerative Hyperplasia | 995 |
Noncirrhotic Portal Fibrosis Idiopathic Portal Hypertension | 996 |
Acute Hepatic Failure S W SCHALM R J DE KNEGT H J METSELAAR and B VAN DEN BERG | 999 |
Etiology | 1000 |
Clinical Features | 1002 |
Prognosis | 1005 |
Medical Treatment | 1006 |
Liver Transplantation for Acute Hepatic Failure | 1013 |
1015 | |
Tumors of the Liver and Biliary Tract M COLOMBO O BELOQUI and B SANGRO | 1019 |
Benign Liver Tumors of Adulthood | 1039 |
Liver Tumors of Childhood | 1047 |
Tumors of the Gallbladder | 1050 |
References | 1051 |
Liver Transplantation E ELIAS and P BURRA | 1057 |
Timing of Transplantation | 1062 |
Results | 1065 |
Conclusion | 1066 |
References | 1067 |
Gallstones J A SUMMERFIELD | 1072 |
Natural History of Gallstones | 1074 |
Treatment of Gallstones | 1079 |
References | 1087 |
1093 | |
Inne wydania - Wyświetl wszystko
Hepatobiliary Diseases Jesús Ma Prieto Valtueña,Jesús Prieto,Joan Rodés,David A. Shafritz Widok fragmentu - 1992 |
Kluczowe wyrazy i wyrażenia
abnormalities acute hepatitis albumin alkaline phosphatase aminotransferase anti-HCV antibodies antigen arterial ascites associated autoimmune bile acids bile ducts bile salts bilirubin biochemical bleeding canalicular cause cholestasis cholestatic chronic active hepatitis chronic hepatitis chronic liver disease cirrhotic patients Clin clinical copper cysts decrease deficiency detected develop diagnosis disorders drugs effects encephalopathy enzyme ethanol excretion extrahepatic factors fatty fibrosis gallbladder Gastroenterology gene haemochromatosis HBsAg HBV DNA hepatitis B virus hepatocellular carcinoma hepatocytes Hepatol Hepatology hepatomegaly histologic increased infection infiltration inflammatory interferon intestinal intrahepatic intrahepatic bile ducts iron jaundice Lancet lesions levels liver biopsy liver cell liver cirrhosis lymphocytes membrane metabolism necrosis non-A non-B hepatitis normal observed obstruction occur pathogenesis periportal plasma porphyria portal hypertension portal tracts present primary biliary cirrhosis protein renal replication serum shunt sinusoidal sodium specific studies syndrome synthesis therapy tissue treatment usually varices vascular vein viral hepatitis vitamin Wilson's disease