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Total Synthesis of Laudanosine.-Amé Pictet and M. Finkelstein. Laudanosine can be synthesised by the following operations:-(1) Preparation of homoveratrylamine, (CH3)2C6H3—CH2—CH2-NH2, by the action of sodium hypobromite on dimethylhydrocaffeic amide, (CH3O)2C6H3-CH2-CH2-CO-NH2; (2) preparation of homoveratric acid from eugenol and transformation into the chloride (CH3O)2C6H3—ČH2-COC1; (3) combination of this chloride with homoveratrylamine in presence of caustic soda, thus obtaining homoveratryl-homoveratrylamine, (CH3O)2C6H3-CH2-CH2- NH-CO-CH2-C6H3(OCH3)2; (4) treatment of this compound with phosphoric anhydride when dihydropapaverine is formed; (5) transformation of dihydropapaverine into its chlormethylate and reduction of the latter by tin and hydrochloric acid. The product is racemic methyltetrahydropapaverine, which under the action of quinic acid gives the dextroisomer, which is

identical with natural laudanosine.

Catalytic Preparation of Ketones.-J. B. Senderens. -Anhydrous ThO2 is a catalytic agent which very readily converts free acids into acetones. Thus diethylketone, C2H5-CO-C2H5, is rapidly obtained from propionic acid. In the case of formic acid formic aldehyde is obtained HCO OH according to the equation HCO OH - H2O + CO2 + HCHO. But formic acid is decomposed at 260° into carbon monoxide and water, and with alumina these are the only products. With thoria, however, the liquid obtained is a mixture of formaldehyde and unchanged acid.

Formation of Peroxides in the Oxidation of OrganoMagnesium Compounds.-H. Wuyts.-The author has shown that when ethereal magnesium solutions are exposed to the action of oxygen, peroxide compounds are formed. Thus a mixture of magnesium ethyl bromide and toluene when treated with dry oxygen at a low temperature becomes capable of setting iodine free from an acetic solution of potassium iodide. Hydroquinone gives an intense coloration with a magnesium organo-compound in pure oxygen, while in hydrogen no coloration is produced. In absence of air diphenylamine gives a colourless liquid, while in air a blue coloration is produced, and a blue coloration is also obtained by ethyl sulphide and paradimethylaminophenyl. These colour reactions can most easily be explained by assuming the presence of peroxidised compounds.

Tetrahydronaphthylglycols (cis and trans) and their Combination.-Henri Leroux.-Dibromide of dihydronaphthalene and silver acetate in boiling acetic solution yeld an ethereal solution from which two substances of formula C10H1202 can be isolated. The one which fuses at 118° is the trans-isomer, and the other

fusing at 140° the cis-isomer. The proportion of cis and trans isomer formed varies according to the circumstances of the experiment, and apparently the dibromide of dihydronaphthalene itself is a combination of cis and trans

isomer.

MISCELLANEOUS.

Association of Teachers in Technical Institutions. -The Annual Conference of the Association will be held this year at Liverpool. The conference will be opened on Whit-Monday by Alderman Wm. Oulton, Chairman of the Liverpool Education Committee. On Tuesday, June 1st, the proceedings will be opened by the Right Hon. the Lord Mayor of Liverpool, H. Chaloner Dowdall, Esq. On Tuesday afternoon there will be a reception by the Lord Mayor and Lady Mayoress at the Town Hall. On

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Royal Institution.-On Tuesday next, June 1, at 3 o'clock, Dr. F. Gowland Hopkins begins a course of two lectures at the Royal Institution on Biological Chemistry"; on June 3, Prof. W. E. Dalby commences a course of two lectures on "A Modern Railway ProblemSteam v. Electricity"; and on Saturday, June 5, Dr. F. F. Blackman delivers the first of two lectures on "The Vitality of Seeds and Plants "—(1) "A Vindication of the Vitality of Plants"; (2) "The Life and Death of Seeds." The Friday Evening Discourse on June 4 will be delivered by Prof. J. A. Fleming on "Researches in Radiotelegraphy"; and on June 11, by Prof. Sir James Dewar, on "Problems of Helium and Radium." An extra discourse will be delivered on June 18 by Mr. A. Henry Savage Landor on "A Recent Visit to the Panama Canal."

A New Company has been formed entitled the CowperColes Engineering Co., Ltd., with a working capital of Victoria Street, S. W. The company has been registered £40,000, and its offices are at Grosvenor Mansions, 82, as a private company, and no issue will be made to the public. The objects of the company are to develop the business of Sherard Cowper-Coles and Co., Ltd., and to carry on the work of electro-metallurgists and chemical engineers. The company will have a large exhibit of their special products, machinery, and apparatus at the forthcoming London International Exhibition. Amongst other things will be exhibited in operation a process for welding aluminium, a regenerative process of electro-galvanising, a centrifugal process for the direct production of copper sheets and tubes, a process of vapour-galvanising; samples and specimens of Mr. Sherard Cowper-Coles' process for producing iron sheets and tubes without smelting or rolling will also be exhibited, and parabolic reflectors for locomotive and motor car headlights and searchlights, the latter constructed so as to throw yellow and white beams of light, which have great advantages for naval and military purposes. Samples and specimens of the firm's process for ornamenting and decorating metallic surfaces, and a variety of other electro-chemical processes and apparatus will also be shown.

MEETINGS FOR THE WEEK.

TUESDAY, June 1st.-Royal Institution, 3. "Biological Chemistry," THURSDAY, 3rd.-Royal Institution, 3. "A Modern Railway Problem -Steam v. Electricity," by Prof. W. E. Dalby. Chemical, 8.30. "Wolcott Gibbs Memorial Lecture," by F. W. Clarke. "Molecular Weight of Tetraethylammonium Bromide and the Atomic Weight of Carbon," by A. Scott. "Rate of Formation of Azo-derivatives from Benzenoid Diamines, by V. H. Veley. "Synthesis of Substances allied to Cotarnine," by A. H. Salway. "Monomethylfructose and its Derivatives-Constitution of Fructosediacetone," by J. C. Irvine and A. Hind. "Optically Active 8-Oximinohexahydrobenzoic Acid and the Configuration of the Oximino-group," by W. H. Mills and Miss A. M. Bain. FRIDAY, 4th.-Royal Institution, 9. "Researches in Radio-telegraphy," by Prof. J. A. Fleming, F.R.S. SATURDAY, 3rd.-Royal Institution, 3. "The Vitality of Seeds and Plants," by F. F. Blackman, F.R.S., &c.

by F. Gowland Hopkins, F.R.S., &c.

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CONTENTS.

ARTICLES:

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Seventh International Congress of Applied Chemistry
Copper as a Reducing Agent for Ferric Salts previous to their
Estimation Volumetrically by A. Colet Birch

265

273

The Quantitative Determination of Nickel with Dimethylglyoxime as applied to various Materials

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MEETINGS FOR THE WEEK

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......

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